Version 5.4
| Bos taurus Protein: FBXL2 | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-696771.2 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | FBXL2 | ||||||||
| Protein Name | F-box/LRR-repeat protein 2 | ||||||||
| Synonyms | FBL2; | ||||||||
| Species | Bos taurus | ||||||||
| Ensembl Protein | ENSBTAP00000005160 | ||||||||
| InnateDB Gene | IDBG-644156 (FBXL2) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | Calcium-activated substrate recognition component of a SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlike many F-box proteins, FBXL2 doesn't seem to target phosphodegron within its substrates but rather calmodulin-binding motifs. Targets PCYT1A for its monoubiquitination and degradation, this is antagonized by calmodulin. Targets the cyclins CCND2 and CCND3 for polyubiquitination and degradation, leading to cell-cycle arrest in G(0), also antagonized by calmodulin (By similarity). {ECO:0000250}. | ||||||||
| Subcellular Localization | Membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | |||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | |||||||||
| InterPro |
IPR001810
F-box domain IPR006553 Leucine-rich repeat, cysteine-containing subtype |
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| PFAM |
PF00646
PF12937 PF13013 |
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| PRINTS | |||||||||
| PIRSF | |||||||||
| SMART |
SM00256
SM00367 |
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| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | A6H779 | ||||||||
| PhosphoSite | PhosphoSite- | ||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 616212 | ||||||||
| UniGene | Bt.54599 | ||||||||
| RefSeq | NP_001092623 | ||||||||
| HUGO | |||||||||
| OMIM | |||||||||
| CCDS | |||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | BC146145 | ||||||||
| GenPept | AAI46146 | ||||||||