Version 5.4
Bos taurus Protein: SERPINE2
Summary
InnateDB Protein IDBP-696808.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SERPINE2
Protein Name Nexin
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000011485
InnateDB Gene IDBG-644187 (SERPINE2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0005539 glycosaminoglycan binding
GO:0008201 heparin binding
Biological Process
GO:0007596 blood coagulation
GO:0008285 negative regulation of cell proliferation
GO:0009611 response to wounding
GO:0010466 negative regulation of peptidase activity
GO:0010544 negative regulation of platelet activation
GO:0010757 negative regulation of plasminogen activation
GO:0010766 negative regulation of sodium ion transport
GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling
GO:0021683 cerebellar granular layer morphogenesis
GO:0030195 negative regulation of blood coagulation
GO:0030308 negative regulation of cell growth
GO:0032940 secretion by cell
GO:0033363 secretory granule organization
GO:0042177 negative regulation of protein catabolic process
GO:0042628 mating plug formation
GO:0045861 negative regulation of proteolysis
GO:0045879 negative regulation of smoothened signaling pathway
GO:0048505 regulation of timing of cell differentiation
GO:0048711 positive regulation of astrocyte differentiation
GO:0050974 detection of mechanical stimulus involved in sensory perception
GO:0051966 regulation of synaptic transmission, glutamatergic
GO:0060291 long-term synaptic potentiation
GO:0060384 innervation
GO:0061108 seminal vesicle epithelium development
GO:0090331 negative regulation of platelet aggregation
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005829 cytosol
GO:0031012 extracellular matrix
GO:0031091 platelet alpha granule
GO:0031232 extrinsic component of external side of plasma membrane
GO:0031594 neuromuscular junction
Protein Structure and Domains
PDB ID
InterPro IPR023796 Serpin domain
PFAM PF00079
PRINTS
PIRSF
SMART SM00093
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q9N1C4
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq
HUGO HGNC:8951
OMIM
CCDS
HPRD
IMGT
EMBL AF210380 DAAA02006044 DAAA02006045
GenPept AAF25881

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca