Version 5.4
Bos taurus Protein: BT.47460
Summary
InnateDB Protein IDBP-696837.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.47460
Protein Name TIR domain-containing adapter molecule 1
Synonyms TRIF;
Species Bos taurus
Ensembl Protein ENSBTAP00000026593
InnateDB Gene IDBG-644220 (BT.47460)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 49 interaction(s) predicted by orthology.
Predicted by orthology
Total 49 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0019901 protein kinase binding
Biological Process
GO:0002281 macrophage activation involved in immune response
GO:0002756 MyD88-independent toll-like receptor signaling pathway
GO:0007165 signal transduction
GO:0030890 positive regulation of B cell proliferation
GO:0031398 positive regulation of protein ubiquitination
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0032092 positive regulation of protein binding
GO:0032481 positive regulation of type I interferon production
GO:0032496 response to lipopolysaccharide
GO:0032755 positive regulation of interleukin-6 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032816 positive regulation of natural killer cell activation
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043330 response to exogenous dsRNA
GO:0043496 regulation of protein homodimerization activity
GO:0045080 positive regulation of chemokine biosynthetic process
GO:0045087 innate immune response
GO:0045359 positive regulation of interferon-beta biosynthetic process
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0050871 positive regulation of B cell activation
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051607 defense response to virus
GO:0097190 apoptotic signaling pathway
Cellular Component
GO:0097342 ripoptosome
Protein Structure and Domains
PDB ID
InterPro IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
IPR017278 TIR domain-containing adapter molecule 1
PFAM PF01582
PF13676
PRINTS
PIRSF PIRSF037744
SMART SM00255
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL F1N4G5
UniProt Splice Variant
Entrez Gene 510427
UniGene Bt.47460
RefSeq NP_001025472
HUGO HGNC:18348
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02019596
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca