InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: WDYHV1

Summary

InnateDB Protein

IDBP-696856.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

WDYHV1

Protein Name

Protein N-terminal glutamine amidohydrolase

Synonyms

C14H8orf32; C8orf32;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000045021

InnateDB Gene

IDBG-644234 (WDYHV1)

Protein Structure

UniProt Annotation

Function

Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N- terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C- terminal glutamine and does not act on non-glutamine residues in any position. Does not deaminate acetylated N-terminal glutamine. With the exception of proline, all tested second-position residues on substrate peptides do not greatly influence the activity. In contrast, a proline at position 2, virtually abolishes deamidation of N-terminal glutamine (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000250}. Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0016787	hydrolase activity
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
GO:0070773	protein-N-terminal glutamine amidohydrolase activity

Biological Process

GO:0006464

cellular protein modification process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR023128 Protein N-terminal glutamine amidohydrolase, alpha beta roll

PFAM

PF09764

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q3T0D3

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

510463

UniGene

Bt.9348

RefSeq

NP_001030263

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC102447 DV842245

GenPept

AAI02448