Version 5.4
Bos taurus Protein: MFF
Summary
InnateDB Protein IDBP-696886.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MFF
Protein Name Mitochondrial fission factor
Synonyms C2H2orf33; C2orf33;
Species Bos taurus
Ensembl Protein ENSBTAP00000028425
InnateDB Gene IDBG-644240 (MFF)
Protein Structure
UniProt Annotation
Function Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles (By similarity). {ECO:0000250}.
Subcellular Localization Mitochondrion outer membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Peroxisome {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0042803 protein homodimerization activity
Biological Process
GO:0000266 mitochondrial fission
GO:0008053 mitochondrial fusion
GO:0090141 positive regulation of mitochondrial fission
GO:0090314 positive regulation of protein targeting to membrane
Cellular Component
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005777 peroxisome
GO:0008021 synaptic vesicle
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0031307 integral component of mitochondrial outer membrane
GO:0031410 cytoplasmic vesicle
GO:0045202 synapse
Protein Structure and Domains
PDB ID
InterPro IPR008518 FATE/Miff/Tango-11
PFAM PF05644
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3ZCD8
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 506291
UniGene Bt.9646
RefSeq NP_001029439
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC102501
GenPept AAI02502

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca