Version 5.4
Bos taurus Protein: CHAF1A
Summary
InnateDB Protein IDBP-696891.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CHAF1A
Protein Name Chromatin assembly factor 1 subunit A
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000010763
InnateDB Gene IDBG-644262 (CHAF1A)
Protein Structure
UniProt Annotation
Function Core component of the CAF-1 complex, a complex thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. CHAF1A binds to histones H3 and H4. It may play a role in heterochromatin maintenance in proliferating cells by bringing newly synthesized cbx proteins to heterochromatic DNA replication foci. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Note=DNA replication foci. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 57 interaction(s) predicted by orthology.
Predicted by orthology
Total 57 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042802 identical protein binding
GO:0070087 chromo shadow domain binding
Biological Process
GO:0006260 DNA replication
GO:0006281 DNA repair
GO:0006335 DNA replication-dependent nucleosome assembly
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006974 cellular response to DNA damage stimulus
GO:0007049 cell cycle
GO:0031497 chromatin assembly
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0033186 CAF-1 complex
GO:0043234 protein complex
Protein Structure and Domains
PDB ID
InterPro IPR022043 Chromatin assembly factor 1 subunit A
PFAM PF12253
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A6QLA6
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 504535
UniGene Bt.42253
RefSeq NP_001095312
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC147896
GenPept AAI47897

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca