InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: SIRT6

Summary

InnateDB Protein

IDBP-696937.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SIRT6

Protein Name

NAD-dependent deacetylase sirtuin-6

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000026521

InnateDB Gene

IDBG-644302 (SIRT6)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0003956	NAD(P)+-protein-arginine ADP-ribosyltransferase activity
GO:0005515	protein binding
GO:0046969	NAD-dependent histone deacetylase activity (H3-K9 specific)
GO:0070403	NAD+ binding

Biological Process

GO:0006471	protein ADP-ribosylation
GO:0010569	regulation of double-strand break repair via homologous recombination
GO:0070932	histone H3 deacetylation

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005724	nuclear telomeric heterochromatin

Protein Structure and Domains

PDB ID

InterPro

IPR003000 Sirtuin family
IPR026590 Sirtuin family, catalytic core domain
IPR029035 DHS-like NAD/FAD-binding domain

PFAM

PF02146

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

A5D7K6

UniProt Splice Variant

Entrez Gene

535416

UniGene

Bt.20024

RefSeq

NP_001091553

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC140592 DAAA02019617

GenPept

AAI40593