Version 5.4
Bos taurus Protein: CREB3L3
Summary
InnateDB Protein IDBP-696943.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CREB3L3
Protein Name Cyclic AMP-responsive element-binding protein 3-like protein 3Processed cyclic AMP-responsive element-binding protein 3-like protein 3
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000013478
InnateDB Gene IDBG-644307 (CREB3L3)
Protein Structure
UniProt Annotation
Function Transcription factor that may act during endoplasmic reticulum stress by activating unfolded protein response target genes. Activated in response to cAMP stimulation. In vitro, binds the cAMP response element (CRE). Activates transcription through box-B element and CRE. Seems to function synergistically with ATF6. In acute inflammatory response, may activate expression of acute phase response (APR) genes. May be involved in growth suppression (By similarity). {ECO:0000250}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.Processed cyclic AMP-responsive element- binding protein 3-like protein 3: Nucleus {ECO:0000255PROSITE- ProRule:PRU00978}. Note=Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001228 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006986 response to unfolded protein
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR004827 Basic-leucine zipper domain
IPR008917 Transcription factor, Skn-1-like, DNA-binding domain
PFAM PF00170
PF07716
PRINTS
PIRSF
SMART SM00338
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3SYZ3
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 513010
UniGene Bt.18871
RefSeq NP_001029604
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC103320
GenPept AAI03321

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca