Version 5.4
Bos taurus Protein: ACVR2B
Summary
InnateDB Protein IDBP-696965.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ACVR2B
Protein Name activin receptor type-2B precursor
Synonyms ActR-IIB; ActRIIB;
Species Bos taurus
Ensembl Protein ENSBTAP00000024095
InnateDB Gene IDBG-644330 (ACVR2B)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Predicted by orthology
Total 23 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004675 transmembrane receptor protein serine/threonine kinase activity
GO:0004702 receptor signaling protein serine/threonine kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005024 transforming growth factor beta-activated receptor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019838 growth factor binding
GO:0048185 activin binding
Biological Process
GO:0001501 skeletal system development
GO:0001702 gastrulation with mouth forming second
GO:0001822 kidney development
GO:0001946 lymphangiogenesis
GO:0001974 blood vessel remodeling
GO:0006355 regulation of transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0007368 determination of left/right symmetry
GO:0007389 pattern specification process
GO:0007498 mesoderm development
GO:0007507 heart development
GO:0009749 response to glucose
GO:0009791 post-embryonic development
GO:0009952 anterior/posterior pattern specification
GO:0009966 regulation of signal transduction
GO:0016310 phosphorylation
GO:0023014 signal transduction by phosphorylation
GO:0030073 insulin secretion
GO:0030324 lung development
GO:0030501 positive regulation of bone mineralization
GO:0030509 BMP signaling pathway
GO:0031016 pancreas development
GO:0032147 activation of protein kinase activity
GO:0032927 positive regulation of activin receptor signaling pathway
GO:0035265 organ growth
GO:0042475 odontogenesis of dentin-containing tooth
GO:0045669 positive regulation of osteoblast differentiation
GO:0048617 embryonic foregut morphogenesis
GO:0048705 skeletal system morphogenesis
GO:0060021 palate development
GO:0060836 lymphatic endothelial cell differentiation
GO:0060840 artery development
GO:0060841 venous blood vessel development
GO:0061298 retina vasculature development in camera-type eye
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043234 protein complex
Protein Structure and Domains
PDB ID
InterPro IPR000333 Ser/Thr protein kinase, TGFB receptor
IPR000472 TGF-beta receptor/activin receptor, type I/II
IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain
PFAM PF01064
PF00069
PF07714
PRINTS PR00653
PR00109
PIRSF
SMART SM00220
SM00219
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL I3PGL0
UniProt Splice Variant
Entrez Gene 282131
UniGene Bt.4990
RefSeq NP_776920
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02053650 HQ703505
GenPept AEX15865

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca