InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: ITM2C

Summary

InnateDB Protein

IDBP-696994.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ITM2C

Protein Name

Integral membrane protein 2CCT-BRI3

Synonyms

ITM3;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000023734

InnateDB Gene

IDBG-644359 (ITM2C)

Protein Structure

UniProt Annotation

Function

Negative regulator of beta amyloid peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C- terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation (By similarity). {ECO:0000250}.

Subcellular Localization

Lysosome membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Cell membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001540	beta-amyloid binding
GO:0005515	protein binding
GO:0005524	ATP binding

Biological Process

GO:0010977	negative regulation of neuron projection development
GO:0030182	neuron differentiation
GO:2001238	positive regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0005764	lysosome
GO:0005765	lysosomal membrane
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR007084 BRICHOS domain

PFAM

PF04089

PRINTS

PIRSF

SMART

SM01039

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

A2VDN0

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

539959

UniGene

Bt.61120

RefSeq

NP_001075007

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC133321

GenPept

AAI33322