Version 5.4
Bos taurus Protein: VAPA
Summary
InnateDB Protein IDBP-697012.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol VAPA
Protein Name Vesicle-associated membrane protein-associated protein A
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000022970
InnateDB Gene IDBG-644380 (VAPA)
Protein Structure
UniProt Annotation
Function May play a role in vesicle trafficking. {ECO:0000250UniProtKB:Q9P0L0}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Note=Present in the plasma membrane and in intracellular vesicles, together with SNARE proteins. May also associate with the cytoskeleton. Colocalizes with OCLN at the tight junction in polarized epithelial cells (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity Ubiquitous. {ECO:0000250UniProtKB:Q9P0L0}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.
Predicted by orthology
Total 31 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0005198 structural molecule activity
GO:0005515 protein binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0007165 signal transduction
GO:0008219 cell death
GO:0031175 neuron projection development
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0070972 protein localization to endoplasmic reticulum
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0005923 tight junction
GO:0015630 microtubule cytoskeleton
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031982 vesicle
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR000535 MSP domain
IPR008962 PapD-like
IPR016763 Vesicle-associated membrane protein
PFAM PF00635
PRINTS
PIRSF PIRSF019693
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q0VCY1
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 516024
UniGene Bt.7886
RefSeq NP_001069201
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC119937
GenPept AAI19938

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca