InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: 5HTR2B

Summary

InnateDB Protein

IDBP-697015.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

5HTR2B

Protein Name

5-hydroxytryptamine 2B receptorUncharacterized protein

Synonyms

5-HT2B; 5HT2B; 5htr2b;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000052700

InnateDB Gene

IDBG-644379 (5HTR2B)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001965	G-protein alpha-subunit binding
GO:0004871	signal transducer activity
GO:0004930	G-protein coupled receptor activity
GO:0004993	serotonin receptor activity
GO:0005099	Ras GTPase activator activity
GO:0008144	drug binding
GO:0051378	serotonin binding

Biological Process

GO:0001755	neural crest cell migration
GO:0001819	positive regulation of cytokine production
GO:0001938	positive regulation of endothelial cell proliferation
GO:0002031	G-protein coupled receptor internalization
GO:0003007	heart morphogenesis
GO:0003300	cardiac muscle hypertrophy
GO:0006182	cGMP biosynthetic process
GO:0006874	cellular calcium ion homeostasis
GO:0006939	smooth muscle contraction
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007202	activation of phospholipase C activity
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007210	serotonin receptor signaling pathway
GO:0007507	heart development
GO:0008284	positive regulation of cell proliferation
GO:0010507	negative regulation of autophagy
GO:0010513	positive regulation of phosphatidylinositol biosynthetic process
GO:0014033	neural crest cell differentiation
GO:0014065	phosphatidylinositol 3-kinase signaling
GO:0014827	intestine smooth muscle contraction
GO:0016310	phosphorylation
GO:0019722	calcium-mediated signaling
GO:0032320	positive regulation of Ras GTPase activity
GO:0042310	vasoconstriction
GO:0042493	response to drug
GO:0043066	negative regulation of apoptotic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043406	positive regulation of MAP kinase activity
GO:0048598	embryonic morphogenesis
GO:0050715	positive regulation of cytokine secretion
GO:0050795	regulation of behavior
GO:0051000	positive regulation of nitric-oxide synthase activity
GO:0051209	release of sequestered calcium ion into cytosol
GO:0051781	positive regulation of cell division
GO:0060548	negative regulation of cell death
GO:0070371	ERK1 and ERK2 cascade
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0070528	protein kinase C signaling
GO:0071502	cellular response to temperature stimulus

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000482 5-Hydroxytryptamine 2B receptor
IPR002231 5-hydroxytryptamine receptor family
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF10320

PRINTS

PR00237
PR00651
PR01101

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite