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InnateDB Protein
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IDBP-697087.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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COPS7B
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Protein Name
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COP9 signalosome complex subunit 7b
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Synonyms
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Species
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Bos taurus
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Ensembl Protein
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ENSBTAP00000006858
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InnateDB Gene
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IDBG-644446 (COPS7B)
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Protein Structure
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| Function |
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively (By similarity). {ECO:0000250}.
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| Subcellular Localization |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
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| Disease Associations |
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| Tissue Specificity |
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.
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| Predicted by orthology |
| Total |
25 [view]
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Molecular Function |
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| Biological Process |
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| Cellular Component |
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| PDB ID |
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| InterPro |
IPR000717
Proteasome component (PCI) domain
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| PFAM |
PF01399
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| PRINTS |
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| PIRSF |
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| SMART |
SM00088
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| TIGRFAMs |
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| Modification |
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| SwissProt |
Q2KI56
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| PhosphoSite |
PhosphoSite-
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| TrEMBL |
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| UniProt Splice Variant |
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| Entrez Gene |
617995
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| UniGene |
Bt.26541
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| RefSeq |
NP_001040077
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| HUGO |
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| OMIM |
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| CCDS |
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| HPRD |
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| IMGT |
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| EMBL |
BC112763
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| GenPept |
AAI12764
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Version 5.4