InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: AFG3L2

Summary

InnateDB Protein

IDBP-697103.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AFG3L2

Protein Name

AFG3-like protein 2

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000030993

InnateDB Gene

IDBG-644462 (AFG3L2)

Protein Structure

UniProt Annotation

Function

Putative ATP-dependent protease. {ECO:0000250}.

Subcellular Localization

Mitochondrion membrane {ECO:0000250}; Multi- pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004222	metalloendopeptidase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008233	peptidase activity
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding
GO:0016787	hydrolase activity
GO:0017111	nucleoside-triphosphatase activity
GO:0046872	metal ion binding

Biological Process

GO:0006508	proteolysis
GO:0007005	mitochondrion organization
GO:0007409	axonogenesis
GO:0007528	neuromuscular junction development
GO:0008053	mitochondrial fusion
GO:0016265	death
GO:0021675	nerve development
GO:0034982	mitochondrial protein processing
GO:0040014	regulation of multicellular organism growth
GO:0042407	cristae formation
GO:0042552	myelination
GO:0048747	muscle fiber development
GO:0060013	righting reflex

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031966	mitochondrial membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000642 Peptidase M41
IPR003593 AAA+ ATPase domain
IPR003959 ATPase, AAA-type, core
IPR005936 Peptidase, FtsH
IPR011546 Peptidase M41, FtsH extracellular
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF01434
PF00004
PF07724
PF13304
PF06480

PRINTS

PIRSF

SMART

SM00382

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q2KJI7