Version 5.4
Bos taurus Protein: PENK
Summary
InnateDB Protein IDBP-697112.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PENK
Protein Name Proenkephalin-ASynenkephalinMet-enkephalinPENK(111-130)PENK(140-179)Met-enkephalin-Arg-Gly-LeuLeu-enkephalinEnkelytinPENK(233-254)Met-enkephalin-Arg-Phe
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000006478
InnateDB Gene IDBG-644471 (PENK)
Protein Structure
UniProt Annotation
Function Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. PENK(111-130) and PENK(233-254) increase glutamate release in the striatum. PENK(111-130) decreases GABA concentration in the striatum.Enkelytin possesses antibacterial activity against Gram- positive bacteria such as Micrococcus luteus and Bacillus megaterium.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001515 opioid peptide activity
GO:0005515 protein binding
Biological Process
GO:0001662 behavioral fear response
GO:0001964 startle response
GO:0002118 aggressive behavior
GO:0007218 neuropeptide signaling pathway
GO:0007626 locomotory behavior
GO:0019233 sensory perception of pain
GO:0042742 defense response to bacterium
Cellular Component
GO:0005576 extracellular region
Protein Structure and Domains
PDB ID
InterPro IPR000703 Proenkephalin A
IPR006024 Opioid neuropeptide precursor
PFAM PF01160
PRINTS PR01029
PR01028
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P01211
PhosphoSite PhosphoSite-P01211
TrEMBL
UniProt Splice Variant
Entrez Gene 281387
UniGene Bt.166
RefSeq NP_776566
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC111279 J00012 V00108 V00109
GenPept AAA30673 AAI11280 CAA23442 CAA23443

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca