InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: GADD45B

Summary

InnateDB Protein

IDBP-697151.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GADD45B

Protein Name

Growth arrest and DNA damage-inducible protein GADD45 beta

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000035670

InnateDB Gene

IDBG-644512 (GADD45B)

Protein Structure

UniProt Annotation

Function

Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0000185	activation of MAPKKK activity
GO:0000186	activation of MAPKK activity
GO:0006469	negative regulation of protein kinase activity
GO:0006915	apoptotic process
GO:0006950	response to stress
GO:0007275	multicellular organismal development
GO:0030154	cell differentiation
GO:0043065	positive regulation of apoptotic process
GO:0046330	positive regulation of JNK cascade
GO:0051726	regulation of cell cycle
GO:1900745	positive regulation of p38MAPK cascade

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR004038 Ribosomal protein L7Ae/L30e/S12e/Gadd45
IPR029064 50S ribosomal protein L30e-like

PFAM

PF01248

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q5E9A5

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

618405

UniGene

Bt.4371

RefSeq

NP_001035694

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC113347 BT021015

GenPept

AAI13348 AAX09032