InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: MC2R

Summary

InnateDB Protein

IDBP-697171.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MC2R

Protein Name

Adrenocorticotropic hormone receptor

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000014661

InnateDB Gene

IDBG-644530 (MC2R)

Protein Structure

UniProt Annotation

Function

Receptor for corticotropin (ACTH). This receptor is mediated by G proteins which activate adenylate cyclase (cAMP).

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Melanocytes and corticoadrenal tissue.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0004930	G-protein coupled receptor activity
GO:0004977	melanocortin receptor activity
GO:0004978	corticotropin receptor activity
GO:0005515	protein binding

Biological Process

GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007218	neuropeptide signaling pathway
GO:0030819	positive regulation of cAMP biosynthetic process

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR001168 Adrenocorticotrophin (ACTH) receptor
IPR001671 Melanocortin/ACTH receptor
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
IPR019430 7TM GPCR, serpentine receptor class x (Srx)

PFAM

PF00001
PF10320
PF10328

PRINTS

PR00237
PR00520
PR00534

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P34974