InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: SF3A2

Summary

InnateDB Protein

IDBP-697254.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SF3A2

Protein Name

Splicing factor 3A subunit 2

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000035656

InnateDB Gene

IDBG-644605 (SF3A2)

Protein Structure

UniProt Annotation

Function

Subunit of the splicing factor SF3A required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00130}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 116 interaction(s) predicted by orthology.

Predicted by orthology
Total	116 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0044822	poly(A) RNA binding
GO:0046872	metal ion binding

Biological Process

GO:0006397	mRNA processing
GO:0008380	RNA splicing

Cellular Component

GO:0005634	nucleus
GO:0005681	spliceosomal complex
GO:0071013	catalytic step 2 spliceosome

Protein Structure and Domains

PDB ID

InterPro

IPR000690 Zinc finger, C2H2-type matrin
IPR003604 Zinc finger, U1-type

PFAM

PRINTS

PIRSF

SMART

SM00451

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

A5PJN8

PhosphoSite

PhosphoSite-

TrEMBL

G3MW14

UniProt Splice Variant

Entrez Gene

789082

UniGene

Bt.27293

RefSeq

NP_001092681

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC142185 DAAA02019685

GenPept

AAI42186