Version 5.4
Bos taurus Protein: RCE1
Summary
InnateDB Protein IDBP-697283.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RCE1
Protein Name CAAX prenyl protease 2
Synonyms FACE-2;
Species Bos taurus
Ensembl Protein ENSBTAP00000042314
InnateDB Gene IDBG-644634 (RCE1)
Protein Structure
UniProt Annotation
Function Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins. Seems to be able to process K-Ras, N-Ras, H-Ras, RAP1B and G-gamma-1 (By similarity). {ECO:0000250}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004197 cysteine-type endopeptidase activity
GO:0016787 hydrolase activity
Biological Process
GO:0006508 proteolysis
GO:0071586 CAAX-box protein processing
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR003675 CAAX amino terminal protease
PFAM PF02517
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A6H7A0
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 539539
UniGene Bt.20244
RefSeq NP_001092567
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC146167
GenPept AAI46168

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca