InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: PC

Summary

InnateDB Protein

IDBP-697292.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Protein Name

Pyruvate carboxylase, mitochondrial

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000030027

InnateDB Gene

IDBG-644637 (PC)

Protein Structure

UniProt Annotation

Function

Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion matrix {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003677	DNA binding
GO:0003824	catalytic activity
GO:0004075	biotin carboxylase activity
GO:0004736	pyruvate carboxylase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008716	D-alanine-D-alanine ligase activity
GO:0016874	ligase activity
GO:0046872	metal ion binding

Biological Process

GO:0006094	gluconeogenesis
GO:0006629	lipid metabolic process
GO:0008152	metabolic process

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005759	mitochondrial matrix

Protein Structure and Domains

PDB ID

InterPro

IPR000089 Biotin/lipoyl attachment
IPR000891 Pyruvate carboxyltransferase
IPR003379 Carboxylase, conserved domain
IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain
IPR005481 Carbamoyl-phosphate synthase, large subunit, N-terminal
IPR005482 Biotin carboxylase, C-terminal
IPR005930 Pyruvate carboxylase
IPR011053 Single hybrid motif
IPR011054 Rudiment single hybrid motif
IPR011095 D-alanine--D-alanine ligase, C-terminal
IPR011761 ATP-grasp fold
IPR011764 Biotin carboxylation domain
IPR016185 Pre-ATP-grasp domain

PFAM