Version 5.4
Bos taurus Protein: ACAA2
Summary
InnateDB Protein IDBP-697323.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ACAA2
Protein Name 3-ketoacyl-CoA thiolase, mitochondrial
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000003716
InnateDB Gene IDBG-644670 (ACAA2)
Protein Structure
UniProt Annotation
Function Abolishes BNIP3-mediated apoptosis and mitochondrial damage. {ECO:0000250}.
Subcellular Localization Mitochondrion {ECO:0000250}. Note=Colocalizes with BNIP3 in the mitochondria. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0003988 acetyl-CoA C-acyltransferase activity
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0016746 transferase activity, transferring acyl groups
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006629 lipid metabolic process
GO:0006631 fatty acid metabolic process
GO:0008152 metabolic process
GO:0071456 cellular response to hypoxia
GO:1901029 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:1902109 negative regulation of mitochondrial membrane permeability involved in apoptotic process
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR002155 Thiolase
IPR016039 Thiolase-like
IPR020616 Thiolase, N-terminal
IPR020617 Thiolase, C-terminal
PFAM PF00108
PF02803
PRINTS
PIRSF PIRSF000429
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3T0R7
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 522006
UniGene Bt.48847
RefSeq NP_001030419
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC102287 BT025480 EF583004 EF583005
GenPept AAI02288 ABF57436 ABU62844 ABU62845

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca