Version 5.4
| Bos taurus Protein: HCRTR1 | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-697381.2 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | HCRTR1 | ||||||||
| Protein Name | Orexin receptor type 1 | ||||||||
| Synonyms | |||||||||
| Species | Bos taurus | ||||||||
| Ensembl Protein | ENSBTAP00000013687 | ||||||||
| InnateDB Gene | IDBG-644721 (HCRTR1) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Seems to be exclusively coupled to the G(q) subclass of heteromeric G proteins, which activates the phospholipase C mediated signaling cascade (By similarity). {ECO:0000250}. | ||||||||
| Subcellular Localization | Cell membrane; Multi-pass membrane protein. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | |||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | |||||||||
| InterPro |
IPR000204
Orexin receptor family IPR000276 G protein-coupled receptor, rhodopsin-like IPR000611 Neuropeptide Y receptor family IPR004059 Orexin receptor 1 IPR017452 GPCR, rhodopsin-like, 7TM IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx |
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| PFAM |
PF00001
PF10320 |
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| PRINTS |
PR01064
PR00237 PR01012 PR01521 |
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| PIRSF | |||||||||
| SMART | |||||||||
| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | Q0GBZ5 | ||||||||
| PhosphoSite | PhosphoSite- | ||||||||
| TrEMBL | Q002C2 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 282248 | ||||||||
| UniGene | |||||||||
| RefSeq | NP_001041647 | ||||||||
| HUGO | |||||||||
| OMIM | |||||||||
| CCDS | |||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | DQ874350 DQ981401 DQ986909 DQ986910 DQ986911 DQ986913 DQ986914 DQ986915 DQ986916 | ||||||||
| GenPept | ABI34075 ABI97976 ABJ09769 ABJ09770 ABJ09771 ABJ09773 ABJ09774 ABJ09775 ABJ09776 | ||||||||