Version 5.4
Bos taurus Protein: SMAD4
Summary
InnateDB Protein IDBP-697390.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SMAD4
Protein Name mothers against decapentaplegic homolog 4
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000009081
InnateDB Gene IDBG-644730 (SMAD4)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 205 interaction(s) predicted by orthology.
Predicted by orthology
Total 205 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000987 core promoter proximal region sequence-specific DNA binding
GO:0000988 protein binding transcription factor activity
GO:0001076 RNA polymerase II transcription factor binding transcription factor activity
GO:0001085 RNA polymerase II transcription factor binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0005518 collagen binding
GO:0030616 transforming growth factor beta receptor, common-partner cytoplasmic mediator activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0070411 I-SMAD binding
GO:0070412 R-SMAD binding
Biological Process
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0001666 response to hypoxia
GO:0001701 in utero embryonic development
GO:0001702 gastrulation with mouth forming second
GO:0001822 kidney development
GO:0003190 atrioventricular valve formation
GO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation
GO:0003251 positive regulation of cell proliferation involved in heart valve morphogenesis
GO:0003279 cardiac septum development
GO:0003360 brainstem development
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007183 SMAD protein complex assembly
GO:0007369 gastrulation
GO:0007411 axon guidance
GO:0007492 endoderm development
GO:0007498 mesoderm development
GO:0008283 cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0009952 anterior/posterior pattern specification
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0014033 neural crest cell differentiation
GO:0017015 regulation of transforming growth factor beta receptor signaling pathway
GO:0030308 negative regulation of cell growth
GO:0030509 BMP signaling pathway
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway
GO:0030513 positive regulation of BMP signaling pathway
GO:0032525 somite rostral/caudal axis specification
GO:0032909 regulation of transforming growth factor beta2 production
GO:0035556 intracellular signal transduction
GO:0036302 atrioventricular canal development
GO:0042118 endothelial cell activation
GO:0042127 regulation of cell proliferation
GO:0042177 negative regulation of protein catabolic process
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048589 developmental growth
GO:0048663 neuron fate commitment
GO:0048729 tissue morphogenesis
GO:0048733 sebaceous gland development
GO:0048859 formation of anatomical boundary
GO:0051098 regulation of binding
GO:0051797 regulation of hair follicle development
GO:0060021 palate development
GO:0060391 positive regulation of SMAD protein import into nucleus
GO:0060395 SMAD protein signal transduction
GO:0060548 negative regulation of cell death
GO:0060956 endocardial cell differentiation
GO:0071559 response to transforming growth factor beta
GO:0072133 metanephric mesenchyme morphogenesis
GO:0072134 nephrogenic mesenchyme morphogenesis
Cellular Component
GO:0000790 nuclear chromatin
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0032444 activin responsive factor complex
GO:0071141 SMAD protein complex
Protein Structure and Domains
PDB ID
InterPro IPR001132 SMAD domain, Dwarfin-type
IPR003619 MAD homology 1, Dwarfin-type
IPR008984 SMAD/FHA domain
IPR013019 MAD homology, MH1
PFAM PF03166
PF03165
PRINTS
PIRSF
SMART SM00524
SM00523
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL B0JYL0
UniProt Splice Variant
Entrez Gene 540248
UniGene Bt.70601
RefSeq NP_001069677
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC151330 DAAA02057034
GenPept AAI51331

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca