InnateDB Protein
|
IDBP-697414.2
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
HINT1
|
Protein Name
|
Histidine triad nucleotide-binding protein 1
|
Synonyms
|
|
Species
|
Bos taurus
|
Ensembl Protein
|
ENSBTAP00000014552
|
InnateDB Gene
|
IDBG-644750 (HINT1)
|
Protein Structure
|
|
Function |
Hydrolyzes purine nucleotide phosphoramidates with a single phosphate group, including adenosine 5'monophosphoramidate (AMP-NH2), adenosine 5'monophosphomorpholidate (AMP-morpholidate) and guanosine 5'monophosphomorpholidate (GMP-morpholidate). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase, as well as Met-AMP, His- AMP and Asp-AMP, lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) and AMP-N-alanine methyl ester. Can also convert adenosine 5'-O-phosphorothioate and guanosine 5'-O- phosphorothioate to the corresponding nucleoside 5'-O-phosphates with concomitant release of hydrogen sulfide. In addition, functions as scaffolding protein that modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex and by the complex formed with MITF and CTNNB1. Modulates p53/TP53 levels and p53/TP53-mediated apoptosis. Modulates proteasomal degradation of target proteins by the SCF (SKP2-CUL1-F-box protein) E3 ubiquitin- protein ligase complex (By similarity). {ECO:0000250}.
|
Subcellular Localization |
Cytoplasm. Nucleus {ECO:0000250}.
|
Disease Associations |
|
Tissue Specificity |
Widely expressed.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
|
Predicted by orthology |
Total |
14 [view]
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR001310
Histidine triad (HIT) protein
IPR011146
HIT-like domain
|
PFAM |
PF01230
|
PRINTS |
PR00332
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
P62958
|
PhosphoSite |
PhosphoSite-
|
TrEMBL |
A1XEA3
|
UniProt Splice Variant |
|
Entrez Gene |
327693
|
UniGene |
Bt.88854
|
RefSeq |
NP_787006
|
HUGO |
|
OMIM |
|
CCDS |
|
HPRD |
|
IMGT |
|
EMBL |
BC102553
DQ347568
U09405
|
GenPept |
AAA18396
AAI02554
ABC55277
|
|
|