InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: BT.22305

Summary

InnateDB Protein

IDBP-697494.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.22305

Protein Name

inositol 1,4,5-trisphosphate receptor type 1

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000047903

InnateDB Gene

IDBG-644817 (BT.22305)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 40 interaction(s) predicted by orthology.

Predicted by orthology
Total	40 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005218	intracellular ligand-gated calcium channel activity
GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
GO:0005262	calcium channel activity
GO:0005515	protein binding
GO:0035091	phosphatidylinositol binding

Biological Process

GO:0001666	response to hypoxia
GO:0006810	transport
GO:0006811	ion transport
GO:0006816	calcium ion transport
GO:0009791	post-embryonic development
GO:0032469	endoplasmic reticulum calcium ion homeostasis
GO:0048016	inositol phosphate-mediated signaling
GO:0050882	voluntary musculoskeletal movement
GO:0051209	release of sequestered calcium ion into cytosol
GO:0055085	transmembrane transport
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0070588	calcium ion transmembrane transport

Cellular Component

GO:0005635	nuclear envelope
GO:0005637	nuclear inner membrane
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005955	calcineurin complex
GO:0014069	postsynaptic density
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016529	sarcoplasmic reticulum
GO:0031088	platelet dense granule membrane
GO:0031094	platelet dense tubular network
GO:0043234	protein complex

Protein Structure and Domains

PDB ID

InterPro

IPR000493 Inositol 1,4,5-trisphosphate-binding protein receptor
IPR000699 RIH (RyR and IP3R Homology) domain
IPR005821 Ion transport domain
IPR013662 RyR/IP3R Homology associated domain
IPR014821 Inositol 1,4,5-trisphosphate/ryanodine receptor
IPR016093 MIR motif

PFAM

PF01365
PF00520
PF08454
PF08709
PF02815

PRINTS

PR00779

PIRSF

SMART

SM00472

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt