InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: ALDH3B1

Summary

InnateDB Protein

IDBP-697501.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ALDH3B1

Protein Name

Aldehyde dehydrogenase family 3 member B1

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000017408

InnateDB Gene

IDBG-644834 (ALDH3B1)

Protein Structure

UniProt Annotation

Function

Oxidizes medium and long chain saturated and unsaturated aldehydes. Metabolizes also benzaldehyde. Low activity towards acetaldehyde and 3,4-dihydroxyphenylacetaldehyde. May not metabolize short chain aldehydes. May use both NADP(+) and NAD(+) as cofactors. May have a protective role against the cytotoxicity induced by lipid peroxidation. {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Note=Primarily in the plasma membrane as well as in some punctate structures in the cytoplasm. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity
GO:0016491	oxidoreductase activity
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

Biological Process

GO:0006068	ethanol catabolic process
GO:0006081	cellular aldehyde metabolic process
GO:0008152	metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR012394 Aldehyde dehydrogenase NAD(P)-dependent
IPR015590 Aldehyde dehydrogenase domain
IPR016161 Aldehyde/histidinol dehydrogenase

PFAM

PF00171

PRINTS

PIRSF

PIRSF036492

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q1JPA0

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

511469

UniGene

Bt.111358

RefSeq

XP_005197429

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC147958 BT025453 BT026328

GenPept

AAI47959 ABF57409 ABG81484