Version 5.4
| Bos taurus Protein: TNFRSF11B | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-697545.2 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | TNFRSF11B | ||||||||
| Protein Name | Tumor necrosis factor receptor superfamily member 11B | ||||||||
| Synonyms | |||||||||
| Species | Bos taurus | ||||||||
| Ensembl Protein | ENSBTAP00000009759 | ||||||||
| InnateDB Gene | IDBG-644876 (TNFRSF11B) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis (By similarity). {ECO:0000250}. | ||||||||
| Subcellular Localization | Secreted {ECO:0000250}. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | |||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | |||||||||
| InterPro |
IPR000488
Death domain IPR001368 TNFR/NGFR cysteine-rich region IPR011029 Death-like domain IPR017371 Tumour necrosis factor receptor 11B IPR022323 Tumour necrosis factor receptor 11 |
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| PFAM |
PF00531
PF00020 |
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| PRINTS |
PR01975
PR01961 |
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| PIRSF |
PIRSF038065
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| SMART |
SM00005
SM00208 |
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| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | A5D7R1 | ||||||||
| PhosphoSite | PhosphoSite- | ||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 523822 | ||||||||
| UniGene | Bt.40061 | ||||||||
| RefSeq | NP_001091525 | ||||||||
| HUGO | |||||||||
| OMIM | |||||||||
| CCDS | |||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | BC140651 | ||||||||
| GenPept | AAI40652 | ||||||||