Version 5.4
Bos taurus Protein: MARCH3
Summary
InnateDB Protein IDBP-697565.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MARCH3
Protein Name E3 ubiquitin-protein ligase MARCH3
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000008938
InnateDB Gene IDBG-644898 (MARCH3)
Protein Structure
UniProt Annotation
Function E3 ubiquitin-protein ligase which may be involved in endosomal trafficking. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasmic vesicle membrane; Multi-pass membrane protein. Early endosome membrane {ECO:0000250}; Multi- pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0006897 endocytosis
GO:0016567 protein ubiquitination
Cellular Component
GO:0005764 lysosome
GO:0005768 endosome
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030659 cytoplasmic vesicle membrane
GO:0031410 cytoplasmic vesicle
GO:0031901 early endosome membrane
Protein Structure and Domains
PDB ID
InterPro IPR001841 Zinc finger, RING-type
IPR011016 Zinc finger, RING-CH-type
IPR018957 Zinc finger, C3HC4 RING-type
PFAM PF13639
PF14634
PF12906
PF00097
PRINTS
PIRSF
SMART SM00184
SM00744
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A0JN69
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 520348
UniGene Bt.69979
RefSeq NP_001071409
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC126540
GenPept AAI26541

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca