Version 5.4
Bos taurus Protein: EIF3H
Summary
InnateDB Protein IDBP-697566.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EIF3H
Protein Name Eukaryotic translation initiation factor 3 subunit H
Synonyms EIF3S3;
Species Bos taurus
Ensembl Protein ENSBTAP00000018645
InnateDB Gene IDBG-644896 (EIF3H)
Protein Structure
UniProt Annotation
Function Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. {ECO:0000255HAMAP- Rule:MF_03007}.
Subcellular Localization Cytoplasm {ECO:0000255HAMAP-Rule:MF_03007}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 58 interaction(s) predicted by orthology.
Predicted by orthology
Total 58 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003743 translation initiation factor activity
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0001731 formation of translation preinitiation complex
GO:0006412 translation
GO:0006413 translational initiation
Cellular Component
GO:0005737 cytoplasm
GO:0005852 eukaryotic translation initiation factor 3 complex
GO:0016020 membrane
GO:0016282 eukaryotic 43S preinitiation complex
GO:0033290 eukaryotic 48S preinitiation complex
GO:0070062 extracellular vesicular exosome
GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m
Protein Structure and Domains
PDB ID
InterPro IPR000555 JAB1/MPN/MOV34 metalloenzyme domain
PFAM PF01398
PRINTS
PIRSF
SMART SM00232
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q56JZ5
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 506873
UniGene
RefSeq NP_001020493
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AY911332 BC102096
GenPept AAI02097 AAW82100

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca