Version 5.4
Bos taurus Protein: ATPIF1
Summary
InnateDB Protein IDBP-697572.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ATPIF1
Protein Name ATPase inhibitor, mitochondrial
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000008319
InnateDB Gene IDBG-644906 (ATPIF1)
Protein Structure
UniProt Annotation
Function Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase. {ECO:0000269PubMed:10831597, ECO:0000269PubMed:12923572, ECO:0000269PubMed:17895376, ECO:0000269PubMed:18687699, ECO:0000269PubMed:21192948, ECO:0000269PubMed:7397110}.
Subcellular Localization Mitochondrion {ECO:0000269PubMed:7397110}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004857 enzyme inhibitor activity
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0042030 ATPase inhibitor activity
GO:0042803 protein homodimerization activity
GO:0043532 angiostatin binding
GO:0051117 ATPase binding
Biological Process
GO:0001937 negative regulation of endothelial cell proliferation
GO:0006783 heme biosynthetic process
GO:0030218 erythrocyte differentiation
GO:0045980 negative regulation of nucleotide metabolic process
GO:0051260 protein homooligomerization
GO:0051289 protein homotetramerization
GO:0051346 negative regulation of hydrolase activity
Cellular Component
GO:0005739 mitochondrion
GO:0009986 cell surface
Protein Structure and Domains
PDB ID
InterPro IPR007648 ATPase inhibitor, IATP, mitochondria
PFAM PF04568
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P01096
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 327699
UniGene Bt.59150
RefSeq NP_787010
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC111645 M22559
GenPept AAA30396 AAI11646

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca