Version 5.4
Bos taurus Protein: LRP5
Summary
InnateDB Protein IDBP-697581.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LRP5
Protein Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000007756
InnateDB Gene IDBG-644859 (LRP5)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0017147 Wnt-protein binding
GO:0042813 Wnt-activated receptor activity
Biological Process
GO:0001702 gastrulation with mouth forming second
GO:0001944 vasculature development
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0002076 osteoblast development
GO:0006007 glucose catabolic process
GO:0008203 cholesterol metabolic process
GO:0008217 regulation of blood pressure
GO:0008284 positive regulation of cell proliferation
GO:0009952 anterior/posterior pattern specification
GO:0016055 Wnt signaling pathway
GO:0033690 positive regulation of osteoblast proliferation
GO:0035019 somatic stem cell maintenance
GO:0035108 limb morphogenesis
GO:0035426 extracellular matrix-cell signaling
GO:0042074 cell migration involved in gastrulation
GO:0042632 cholesterol homeostasis
GO:0042733 embryonic digit morphogenesis
GO:0042981 regulation of apoptotic process
GO:0044332 Wnt signaling pathway involved in dorsal/ventral axis specification
GO:0045600 positive regulation of fat cell differentiation
GO:0045668 negative regulation of osteoblast differentiation
GO:0045840 positive regulation of mitosis
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046849 bone remodeling
GO:0046850 regulation of bone remodeling
GO:0048539 bone marrow development
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060033 anatomical structure regression
GO:0060042 retina morphogenesis in camera-type eye
GO:0060070 canonical Wnt signaling pathway
GO:0060348 bone development
GO:0060349 bone morphogenesis
GO:0060444 branching involved in mammary gland duct morphogenesis
GO:0060603 mammary gland duct morphogenesis
GO:0060612 adipose tissue development
GO:0060764 cell-cell signaling involved in mammary gland development
GO:0060828 regulation of canonical Wnt signaling pathway
GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0061299 retina vasculature morphogenesis in camera-type eye
GO:0061304 retinal blood vessel morphogenesis
GO:0071901 negative regulation of protein serine/threonine kinase activity
GO:1902262 apoptotic process involved in patterning of blood vessels
Cellular Component
GO:0005739 mitochondrion
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043235 receptor complex
Protein Structure and Domains
PDB ID
InterPro IPR000033 LDLR class B repeat
IPR000742 Epidermal growth factor-like domain
IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
IPR017049 Low density lipoprotein receptor-related protein, 5/6
PFAM PF00058
PF00008
PF00057
PRINTS PR00261
PIRSF PIRSF036314
SMART SM00135
SM00181
SM00192
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q1MW21
UniProt Splice Variant
Entrez Gene 534450
UniGene Bt.68746
RefSeq XP_002699451
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AB257751 DAAA02063644
GenPept BAE93502

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca