Version 5.4
Bos taurus Protein: EIF3E
Summary
InnateDB Protein IDBP-697610.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EIF3E
Protein Name Eukaryotic translation initiation factor 3 subunit E
Synonyms EIF3S6;
Species Bos taurus
Ensembl Protein ENSBTAP00000008809
InnateDB Gene IDBG-644941 (EIF3E)
Protein Structure
UniProt Annotation
Function Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. Required for nonsense- mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway. May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins. {ECO:0000255HAMAP-Rule:MF_03004}.
Subcellular Localization Cytoplasm {ECO:0000255HAMAP-Rule:MF_03004}. Nucleus, PML body {ECO:0000255HAMAP-Rule:MF_03004}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 83 interaction(s) predicted by orthology.
Predicted by orthology
Total 83 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003743 translation initiation factor activity
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
GO:0047485 protein N-terminus binding
Biological Process
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0001731 formation of translation preinitiation complex
GO:0006412 translation
GO:0006413 translational initiation
GO:0006446 regulation of translational initiation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005852 eukaryotic translation initiation factor 3 complex
GO:0016020 membrane
GO:0016282 eukaryotic 43S preinitiation complex
GO:0016605 PML body
GO:0033290 eukaryotic 48S preinitiation complex
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000717 Proteasome component (PCI) domain
IPR016650 Eukaryotic translation initiation factor 3 subunit E
IPR019010 Eukaryotic translation initiation factor 3 subunit E, N-terminal
PFAM PF01399
PF09440
PRINTS
PIRSF PIRSF016255
SMART SM00088
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3T102
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 534165
UniGene Bt.48825
RefSeq NP_001029775
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC102188 BT025478
GenPept AAI02189 ABF57434

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca