Version 5.4
Bos taurus Protein: PTAFR
Summary
InnateDB Protein IDBP-697620.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTAFR
Protein Name Platelet-activating factor receptor
Synonyms PAFr;
Species Bos taurus
Ensembl Protein ENSBTAP00000038567
InnateDB Gene IDBG-644951 (PTAFR)
Protein Structure
UniProt Annotation
Function Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth- muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol- calcium second messenger system. May be involved in the morphological and physical modifications of the oviduct and uterus during the estrus cycle and early pregnancy (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:11438398}; Multi-pass membrane protein {ECO:0000269PubMed:11438398}.
Disease Associations
Tissue Specificity Found in oviductal epithelial and stroma cells. Levels in the oviduct are raised at days 2-4 of both pregnancy and of the estrus cycle. In the endometrium, localization is predominantly to the apical borders of glandular and luminal epithelial cells. Expressed at lower levels in endometrial stromal cells. Levels in the endometrium are increased at day 20 of pregnancy (at protein level). {ECO:0000269PubMed:11403499, ECO:0000269PubMed:11438398}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001530 lipopolysaccharide binding
GO:0001875 lipopolysaccharide receptor activity
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0004992 platelet activating factor receptor activity
GO:0005543 phospholipid binding
Biological Process
GO:0001816 cytokine production
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007565 female pregnancy
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0032496 response to lipopolysaccharide
GO:0032959 inositol trisphosphate biosynthetic process
GO:0048015 phosphatidylinositol-mediated signaling
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
IPR002282 Platelet-activating factor receptor
IPR017452 GPCR, rhodopsin-like, 7TM
PFAM PF00001
PRINTS PR00237
PR01153
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9TTY5
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 518283
UniGene Bt.63372
RefSeq NP_001035628
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AF187321 AJ295321 BC153244
GenPept AAF01439 AAI53245 CAC43290

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca