Version 5.4
Homo sapiens Protein: OSTN
Summary
InnateDB Protein IDBP-69774.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol OSTN
Protein Name osteocrin
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000342356
InnateDB Gene IDBG-69772 (OSTN)
Protein Structure
UniProt Annotation
Function Appears to modulate osteoblastic differentiation. Could also function as an autocrine and paracrine factor linked to glucose metabolism in skeletal muscle (By similarity). {ECO:0000250}.
Subcellular Localization Secreted {ECO:0000269PubMed:14523025}.
Disease Associations
Tissue Specificity Expressed in bone.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005179 hormone activity
Biological Process
GO:0001503 ossification
GO:0003416 endochondral bone growth
GO:0007166 cell surface receptor signaling pathway
GO:0030154 cell differentiation
GO:0030828 positive regulation of cGMP biosynthetic process
GO:0045668 negative regulation of osteoblast differentiation
GO:0046325 negative regulation of glucose import
Cellular Component
GO:0005615 extracellular space
Protein Structure and Domains
PDB ID
InterPro IPR021088 Osteocrin
PFAM PF11037
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P61366
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 344901
UniGene Hs.542820
RefSeq NP_937827
HUGO HGNC:29961
OMIM 610280
CCDS CCDS3299
HPRD 17809
IMGT
EMBL AY398681 AY573933 BC128106 BC128107 CH471052
GenPept AAI28107 AAI28108 AAQ94966 AAS87599 EAW78095

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca