InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: BT.28745

Summary

InnateDB Protein

IDBP-697844.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.28745

Protein Name

proteinase-activated receptor 2 precursor

Synonyms

PAR2;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000046225

InnateDB Gene

IDBG-645161 (BT.28745)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001965	G-protein alpha-subunit binding
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding
GO:0015057	thrombin receptor activity
GO:0031681	G-protein beta-subunit binding

Biological Process

GO:0002286	T cell activation involved in immune response
GO:0002690	positive regulation of leukocyte chemotaxis
GO:0002741	positive regulation of cytokine secretion involved in immune response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007596	blood coagulation
GO:0010804	negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
GO:0030193	regulation of blood coagulation
GO:0030335	positive regulation of cell migration
GO:0030836	positive regulation of actin filament depolymerization
GO:0031274	positive regulation of pseudopodium assembly
GO:0032930	positive regulation of superoxide anion generation
GO:0034137	positive regulation of toll-like receptor 2 signaling pathway
GO:0034140	negative regulation of toll-like receptor 3 signaling pathway
GO:0034141	positive regulation of toll-like receptor 3 signaling pathway
GO:0034145	positive regulation of toll-like receptor 4 signaling pathway
GO:0035025	positive regulation of Rho protein signal transduction
GO:0035926	chemokine (C-C motif) ligand 2 secretion
GO:0042119	neutrophil activation
GO:0043122	regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043311	positive regulation of eosinophil degranulation
GO:0045909	positive regulation of vasodilation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046328	regulation of JNK cascade
GO:0046329	negative regulation of JNK cascade
GO:0046330	positive regulation of JNK cascade
GO:0050702	interleukin-1 beta secretion
GO:0050900	leukocyte migration
GO:0050921	positive regulation of chemotaxis
GO:0050927	positive regulation of positive chemotaxis
GO:0051607	defense response to virus
GO:0060100	positive regulation of phagocytosis, engulfment
GO:0061028	establishment of endothelial barrier
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0070493	thrombin receptor signaling pathway
GO:0070661	leukocyte proliferation
GO:0070963	positive regulation of neutrophil mediated killing of gram-negative bacterium
GO:0072608	interleukin-10 secretion
GO:0072643	interferon-gamma secretion
GO:0090195	chemokine secretion
GO:0090198	negative regulation of chemokine secretion
GO:0097029	mature dendritic cell differentiation
GO:1900135	positive regulation of renin secretion into blood stream
GO:2000484	positive regulation of interleukin-8 secretion
GO:2000778	positive regulation of interleukin-6 secretion

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0031143	pseudopodium

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR002281 Protease-activated receptor 2
IPR003912 Protease-activated receptor
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019427 7TM GPCR, serpentine receptor class w (Srw)

PFAM

PF00001
PF10324

PRINTS

PR00237
PR01152
PR01428

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite