InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: FEZF2

Summary

InnateDB Protein

IDBP-697847.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FEZF2

Protein Name

Fez family zinc finger protein 2

Synonyms

ZNF312;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000027056

InnateDB Gene

IDBG-645162 (FEZF2)

Protein Structure

UniProt Annotation

Function

Transcription repressor. Binds to 5'GCAG-3' core sequence. Required for the specification of corticospinal motor neurons and other subcerebral projection neurons. May play a role in layer and neuronal subtype-specific patterning of subcortical projections and axonal fasciculation. Controls the development of dendritic arborization and spines of large layer V pyramidal neurons (By similarity). May be responsible for mastitis resistance and innate immunity. {ECO:0000250, ECO:0000269PubMed:16611727}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:16611727}.

Disease Associations

Tissue Specificity

Highly expressed in brain and weakly in the mammary gland. Infection enhances expression in the mammary gland and promotes expression of SEMA5A. {ECO:0000269PubMed:16611727}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007275	multicellular organismal development
GO:0007399	nervous system development
GO:0007411	axon guidance
GO:0007413	axonal fasciculation
GO:0007626	locomotory behavior
GO:0008285	negative regulation of cell proliferation
GO:0016358	dendrite development
GO:0021537	telencephalon development
GO:0021542	dentate gyrus development
GO:0021797	forebrain anterior/posterior pattern specification
GO:0021853	cerebral cortex GABAergic interneuron migration
GO:0021895	cerebral cortex neuron differentiation
GO:0030154	cell differentiation
GO:0030900	forebrain development
GO:0045666	positive regulation of neuron differentiation
GO:0045893	positive regulation of transcription, DNA-templated

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

InterPro

IPR007087 Zinc finger, C2H2
IPR015880 Zinc finger, C2H2-like

PFAM

PF00096

PRINTS

PIRSF

SMART

SM00355

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q2VWH6

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

613683

UniGene

Bt.72101

RefSeq

NP_001033287

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AY644769 AY644770 BC123390

GenPept

AAI23391 AAV85457 AAV85458