Version 5.4
Bos taurus Protein: SH3BGRL3
Summary
InnateDB Protein IDBP-697884.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SH3BGRL3
Protein Name SH3 domain-binding glutamic acid-rich-like protein 3
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000012599
InnateDB Gene IDBG-645170 (SH3BGRL3)
Protein Structure
UniProt Annotation
Function Could act as a modulator of glutaredoxin biological activity. {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005100 Rho GTPase activator activity
GO:0009055 electron carrier activity
GO:0015035 protein disulfide oxidoreductase activity
GO:0030215 semaphorin receptor binding
Biological Process
GO:0030834 regulation of actin filament depolymerization
GO:0032321 positive regulation of Rho GTPase activity
GO:0032956 regulation of actin cytoskeleton organization
GO:0043535 regulation of blood vessel endothelial cell migration
GO:0045454 cell redox homeostasis
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0030027 lamellipodium
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR002109 Glutaredoxin
IPR006993 SH3-binding, glutamic acid-rich protein
IPR012336 Thioredoxin-like fold
PFAM PF00462
PF04908
PF13098
PF13192
PF13462
PF13905
PRINTS
PIRSF PIRSF008142
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3ZCL8
PhosphoSite PhosphoSite-
TrEMBL G3X6S5
UniProt Splice Variant
Entrez Gene 614672
UniGene
RefSeq NP_001029935
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC102048 DAAA02006375
GenPept AAI02049

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca