Version 5.4
Bos taurus Protein: BHMT
Summary
InnateDB Protein IDBP-697927.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BHMT
Protein Name Betaine--homocysteine S-methyltransferase 1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000002916
InnateDB Gene IDBG-645235 (BHMT)
Protein Structure
UniProt Annotation
Function Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0008168 methyltransferase activity
GO:0008270 zinc ion binding
GO:0008898 S-adenosylmethionine-homocysteine S-methyltransferase activity
GO:0016740 transferase activity
GO:0046872 metal ion binding
GO:0047150 betaine-homocysteine S-methyltransferase activity
GO:0061627 S-methylmethionine-homocysteine S-methyltransferase activity
Biological Process
GO:0006577 amino-acid betaine metabolic process
GO:0006579 amino-acid betaine catabolic process
GO:0009086 methionine biosynthetic process
GO:0032259 methylation
GO:0033477 S-methylmethionine metabolic process
GO:0071267 L-methionine salvage
Cellular Component
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR003726 Homocysteine S-methyltransferase
IPR017226 Betaine-homocysteine S-methyltransferase, BHMT
PFAM PF02574
PRINTS
PIRSF PIRSF037505
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5I597
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 497025
UniGene Bt.16399
RefSeq NP_001011679
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AY854632 BC112599
GenPept AAI12600 AAW39034

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca