InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: HOMER1

Summary

InnateDB Protein

IDBP-697941.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HOMER1

Protein Name

Homer protein homolog 1

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000017647

InnateDB Gene

IDBG-645246 (HOMER1)

Protein Structure

UniProt Annotation

Function

Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2 (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Cell junction, synapse {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0044325	ion channel binding

Biological Process

GO:0003009	skeletal muscle contraction
GO:0048148	behavioral response to cocaine
GO:0048741	skeletal muscle fiber development
GO:0048875	chemical homeostasis within a tissue
GO:0051592	response to calcium ion
GO:0051928	positive regulation of calcium ion transport
GO:0090279	regulation of calcium ion import
GO:2001256	regulation of store-operated calcium entry
GO:2001257	regulation of cation channel activity

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0014069	postsynaptic density
GO:0016020	membrane
GO:0030018	Z disc
GO:0030054	cell junction
GO:0030424	axon
GO:0043005	neuron projection
GO:0043034	costamere
GO:0045177	apical part of cell
GO:0045202	synapse
GO:0045211	postsynaptic membrane
GO:0097481	neuronal postsynaptic density

Protein Structure and Domains

PDB ID

InterPro

IPR000697 WH1/EVH1

PFAM

PF00568

PRINTS

PIRSF

SMART

SM00461

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q2KJ56

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

535311

UniGene

Bt.45821

RefSeq

NP_001069520

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC105509

GenPept

AAI05510