InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: PAPD4

Summary

InnateDB Protein

IDBP-697949.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PAPD4

Protein Name

Poly(A) RNA polymerase GLD2

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000008885

InnateDB Gene

IDBG-645252 (PAPD4)

Protein Structure

UniProt Annotation

Function

Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail. In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs. Does not play a role in replication-dependent histone mRNA degradation (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004652	polynucleotide adenylyltransferase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016740	transferase activity
GO:0046872	metal ion binding

Biological Process

GO:0002244	hematopoietic progenitor cell differentiation
GO:0006397	mRNA processing
GO:0043631	RNA polyadenylation
GO:0071044	histone mRNA catabolic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR002058 PAP/25A-associated

PFAM

PF03828

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q2HJ44

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

533862

UniGene

Bt.92095

RefSeq

NP_001039826

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC113319 BT025394

GenPept

AAI13320 ABF57350