Version 5.4
Bos taurus Protein: LDLRAP1
Summary
InnateDB Protein IDBP-697975.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LDLRAP1
Protein Name low density lipoprotein receptor adapter protein 1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000001393
InnateDB Gene IDBG-645279 (LDLRAP1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001540 beta-amyloid binding
GO:0001784 phosphotyrosine binding
GO:0005515 protein binding
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0030159 receptor signaling complex scaffold activity
GO:0030276 clathrin binding
GO:0035591 signaling adaptor activity
GO:0035612 AP-2 adaptor complex binding
GO:0035615 clathrin adaptor activity
GO:0050750 low-density lipoprotein particle receptor binding
Biological Process
GO:0006898 receptor-mediated endocytosis
GO:0009967 positive regulation of signal transduction
GO:0031623 receptor internalization
GO:0042632 cholesterol homeostasis
GO:0042982 amyloid precursor protein metabolic process
GO:0043393 regulation of protein binding
GO:0048260 positive regulation of receptor-mediated endocytosis
GO:0090003 regulation of establishment of protein localization to plasma membrane
GO:0090118 receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport
Cellular Component
GO:0005737 cytoplasm
GO:0005769 early endosome
GO:0005829 cytosol
GO:0005883 neurofilament
GO:0009898 cytoplasmic side of plasma membrane
GO:0009925 basal plasma membrane
GO:0030121 AP-1 adaptor complex
GO:0030122 AP-2 adaptor complex
GO:0055037 recycling endosome
Protein Structure and Domains
PDB ID
InterPro IPR006020 PTB/PI domain
IPR013625 Tensin phosphotyrosine-binding domain
PFAM PF00640
PF14719
PF08416
PRINTS
PIRSF
SMART SM00462
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL A4IFV0
UniProt Splice Variant
Entrez Gene 511199
UniGene Bt.20380
RefSeq NP_001077137
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC134780 DAAA02006393
GenPept AAI34781

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca