Version 5.4
| Bos taurus Protein: BT.18153 | |||||||||||||
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| Summary | |||||||||||||
| InnateDB Protein | IDBP-698014.2 | ||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||
| Gene Symbol | BT.18153 | ||||||||||||
| Protein Name | Dynein heavy chain 12, axonemal | ||||||||||||
| Synonyms | DNAH12; | ||||||||||||
| Species | Bos taurus | ||||||||||||
| Ensembl Protein | ENSBTAP00000021315 | ||||||||||||
| InnateDB Gene | IDBG-645310 (BT.18153) | ||||||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||||||
| Function | Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity). {ECO:0000250}.May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. {ECO:0000250}. | ||||||||||||
| Subcellular Localization | Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000305}. | ||||||||||||
| Disease Associations | |||||||||||||
| Tissue Specificity | |||||||||||||
| Comments | |||||||||||||
| Interactions | |||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||||||
| PDB ID | |||||||||||||
| InterPro |
IPR001496
SOCS protein, C-terminal IPR002110 Ankyrin repeat IPR020683 Ankyrin repeat-containing domain |
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| PFAM |
PF07525
PF00023 PF13606 PF11929 PF12796 |
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| PRINTS |
PR01415
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| PIRSF | |||||||||||||
| SMART |
SM00253
SM00969 SM00248 |
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| TIGRFAMs | |||||||||||||
| Post-translational Modifications | |||||||||||||
| Modification | |||||||||||||
| Cross-References | |||||||||||||
| SwissProt | Q58CT0 | ||||||||||||
| PhosphoSite | PhosphoSite- | ||||||||||||
| TrEMBL | G8JKY1 | ||||||||||||
| UniProt Splice Variant | |||||||||||||
| Entrez Gene | 509431 | ||||||||||||
| UniGene | Bt.18153 | ||||||||||||
| RefSeq | NP_001030242 | ||||||||||||
| HUGO | |||||||||||||
| OMIM | |||||||||||||
| CCDS | |||||||||||||
| HPRD | |||||||||||||
| IMGT | |||||||||||||
| EMBL | BC148874 BT021867 DAAA02054311 | ||||||||||||
| GenPept | AAI48875 AAX46714 | ||||||||||||