InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: PTPLAD1

Summary

InnateDB Protein

IDBP-698081.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PTPLAD1

Protein Name

3-hydroxyacyl-CoA dehydratase 3

Synonyms

HACD3;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000036401

InnateDB Gene

IDBG-645375 (PTPLAD1)

Protein Structure

UniProt Annotation

Function

Responsible for the dehydration step in very long-chain fatty acid (VLCFA) synthesis. Involved in Rac1-signaling pathways leading to the modulation of gene expression.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0016829	lyase activity

Biological Process

GO:0006629	lipid metabolic process
GO:0006631	fatty acid metabolic process
GO:0006633	fatty acid biosynthetic process
GO:0007249	I-kappaB kinase/NF-kappaB signaling
GO:0007254	JNK cascade
GO:0007266	Rho protein signal transduction

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR007052 CS domain
IPR007482 Protein-tyrosine phosphatase-like, PTPLA
IPR008978 HSP20-like chaperone

PFAM

PF04969
PF04387

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

A7YY55

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

100125237

UniGene

Bt.72117

RefSeq

NP_001096786

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC151339

GenPept

AAI51340