|
InnateDB Protein
|
IDBP-698096.2
|
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
|
Gene Symbol
|
PNRC2
|
|
Protein Name
|
Proline-rich nuclear receptor coactivator 2
|
|
Synonyms
|
|
|
Species
|
Bos taurus
|
|
Ensembl Protein
|
ENSBTAP00000040573
|
|
InnateDB Gene
|
IDBG-645393 (PNRC2)
|
|
Protein Structure
|
|
| Function |
Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery. May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs. Required for UPF1/RENT1 localization to the P-body. Also acts as a nuclear receptor coactivator. May play a role in controlling the energy balance between energy storage and energy expenditure (By similarity). {ECO:0000250}.
|
| Subcellular Localization |
Nucleus {ECO:0000250}. Cytoplasm, P-body {ECO:0000250}.
|
| Disease Associations |
|
| Tissue Specificity |
|
| Comments |
|
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
|
|
| Predicted by orthology |
| Total |
20 [view]
|
|
|
Molecular Function |
|
| Biological Process |
|
GO:0000184
|
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
|
|
GO:0006351
|
transcription, DNA-templated
|
|
GO:0006355
|
regulation of transcription, DNA-templated
|
|
| Cellular Component |
|
| PDB ID |
|
| InterPro |
|
| PFAM |
|
| PRINTS |
|
| PIRSF |
|
| SMART |
|
| TIGRFAMs |
|
| Modification |
|
| SwissProt |
Q0VCW6
|
| PhosphoSite |
PhosphoSite-
|
| TrEMBL |
|
| UniProt Splice Variant |
|
| Entrez Gene |
767836
|
| UniGene |
Bt.79946
|
| RefSeq |
NP_001070425
|
| HUGO |
|
| OMIM |
|
| CCDS |
|
| HPRD |
|
| IMGT |
|
| EMBL |
BC119962
|
| GenPept |
AAI19963
|
|
|
|
Version 5.4