InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: SELK

Summary

InnateDB Protein

IDBP-698099.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SELK

Protein Name

selenoprotein K

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000043281

InnateDB Gene

IDBG-645392 (SELK)

Protein Structure

UniProt Annotation

Function

Required for Ca(2+) flux in immune cells and plays a role in T-cell proliferation and in T-cell and neutrophil migration. Involved in endoplasmic reticulum-associated degradation (ERAD) of soluble glycosylated proteins. Required for palmitoylation and cell surface expression of CD36 and involved in macrophage uptake of low-density lipoprotein and in foam cell formation. Plays a role in protection of cells from ER stress- induced apoptosis. Protects cells from oxidative stress when overexpressed in cardiomyocytes (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Cell membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:0006816	calcium ion transport
GO:0010742	macrophage derived foam cell differentiation
GO:0018345	protein palmitoylation
GO:0030335	positive regulation of cell migration
GO:0042102	positive regulation of T cell proliferation
GO:0045728	respiratory burst after phagocytosis
GO:0051223	regulation of protein transport
GO:2000406	positive regulation of T cell migration

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR024491 Selenoprotein SelK/SelG

PFAM

PF10961

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q32PE3

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

615114

UniGene

RefSeq

NP_001032566

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC108150

GenPept

AAI08151