Version 5.4
Bos taurus Protein: ACTR8
Summary
InnateDB Protein IDBP-698103.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ACTR8
Protein Name Actin-related protein 8
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000014847
InnateDB Gene IDBG-645397 (ACTR8)
Protein Structure
UniProt Annotation
Function Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize (By similarity). {ECO:0000250}.Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Required for the recruitment of INO80 (and probably the INO80 complex) to sites of DNA damage Strongly prefer nucleosomes and H3-H4 tetramers over H2A-H2B dimers, suggesting it may act as a nucleosome recognition module within the complex (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Chromosome {ECO:0000250}. Note=Specifically localizes to mitotic chromosomes. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Predicted by orthology
Total 18 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0005515 protein binding
GO:0005524 ATP binding
Biological Process
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0006338 chromatin remodeling
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006974 cellular response to DNA damage stimulus
GO:0007049 cell cycle
GO:0007067 mitotic nuclear division
GO:0051301 cell division
Cellular Component
GO:0005634 nucleus
GO:0005694 chromosome
GO:0031011 Ino80 complex
Protein Structure and Domains
PDB ID
InterPro IPR004000 Actin-related protein
PFAM PF00022
PRINTS PR00190
PIRSF
SMART SM00268
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q1LZF2
PhosphoSite PhosphoSite-
TrEMBL Q0V8C1
UniProt Splice Variant
Entrez Gene 615133
UniGene Bt.12705
RefSeq NP_001069829
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC116036 BT026298
GenPept AAI16037 ABG81454

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca