Version 5.4
Bos taurus Protein: MAP2K1
Summary
InnateDB Protein IDBP-698148.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAP2K1
Protein Name dual specificity mitogen-activated protein kinase kinase 1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000045293
InnateDB Gene IDBG-645446 (MAP2K1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 53 interaction(s) predicted by orthology.
Predicted by orthology
Total 53 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004708 MAP kinase kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004728 receptor signaling protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0043539 protein serine/threonine kinase activator activity
Biological Process
GO:0000187 activation of MAPK activity
GO:0006468 protein phosphorylation
GO:0007050 cell cycle arrest
GO:0008285 negative regulation of cell proliferation
GO:0010628 positive regulation of gene expression
GO:0030182 neuron differentiation
GO:0030216 keratinocyte differentiation
GO:0045597 positive regulation of cell differentiation
GO:0048870 cell motility
GO:0060674 placenta blood vessel development
GO:0060711 labyrinthine layer development
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0090398 cellular senescence
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain
PFAM PF00069
PF07714
PRINTS PR00109
PIRSF
SMART SM00220
SM00219
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q0VD16
UniProt Splice Variant
Entrez Gene 533199
UniGene Bt.87413
RefSeq NP_001124224
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC119886 DAAA02027897 DAAA02027898
GenPept AAI19887

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca