InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: KDM1A

Summary

InnateDB Protein

IDBP-698195.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KDM1A

Protein Name

lysine (K)-specific demethylase 1A

Synonyms

AOF2; KDM1;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000012501

InnateDB Gene

IDBG-645477 (KDM1A)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 104 interaction(s) predicted by orthology.

Predicted by orthology
Total	104 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001085	RNA polymerase II transcription factor binding
GO:0002039	p53 binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0016491	oxidoreductase activity
GO:0019899	enzyme binding
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity
GO:0032451	demethylase activity
GO:0032452	histone demethylase activity
GO:0032453	histone demethylase activity (H3-K4 specific)
GO:0032454	histone demethylase activity (H3-K9 specific)
GO:0034648	histone demethylase activity (H3-dimethyl-K4 specific)
GO:0043426	MRF binding
GO:0044212	transcription regulatory region DNA binding
GO:0050660	flavin adenine dinucleotide binding
GO:0050681	androgen receptor binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001701	in utero embryonic development
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006482	protein demethylation
GO:0008283	cell proliferation
GO:0010725	regulation of primitive erythrocyte differentiation
GO:0021983	pituitary gland development
GO:0030851	granulocyte differentiation
GO:0032091	negative regulation of protein binding
GO:0033169	histone H3-K9 demethylation
GO:0034720	histone H3-K4 demethylation
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0045648	positive regulation of erythrocyte differentiation
GO:0045654	positive regulation of megakaryocyte differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046886	positive regulation of hormone biosynthetic process
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051572	negative regulation of histone H3-K4 methylation
GO:0051573	negative regulation of histone H3-K9 methylation
GO:0055001	muscle cell development
GO:0055114	oxidation-reduction process
GO:1902166	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:2000179	positive regulation of neural precursor cell proliferation
GO:2000648	positive regulation of stem cell proliferation

Cellular Component

GO:0000790	nuclear chromatin
GO:0005634	nucleus
GO:0005667	transcription factor complex

Protein Structure and Domains

PDB ID

InterPro

IPR001327 Pyridine nucleotide-disulphide oxidoreductase, NAD-binding domain
IPR002937 Amine oxidase
IPR003953 FAD binding domain
IPR006076 FAD dependent oxidoreductase
IPR007526 SWIRM domain
IPR009057 Homeodomain-like
IPR017366 Histone lysine-specific demethylase

PFAM

PF00070
PF01593
PF00890
PF01266
PF04433

PRINTS

PIRSF

PIRSF038051

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite