Version 5.4
| Bos taurus Protein: C1QB | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-698202.2 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | C1QB | ||||||||
| Protein Name | Complement C1q subcomponent subunit B | ||||||||
| Synonyms | |||||||||
| Species | Bos taurus | ||||||||
| Ensembl Protein | ENSBTAP00000014871 | ||||||||
| InnateDB Gene | IDBG-645500 (C1QB) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes (By similarity). {ECO:0000250}. | ||||||||
| Subcellular Localization | Secreted {ECO:0000250}. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | |||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | |||||||||
| InterPro |
IPR001073
Complement C1q protein IPR008160 Collagen triple helix repeat IPR008983 Tumour necrosis factor-like domain |
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| PFAM |
PF00386
PF01391 |
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| PRINTS |
PR00007
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| PIRSF | |||||||||
| SMART |
SM00110
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| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | Q2KIV9 | ||||||||
| PhosphoSite | PhosphoSite- | ||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 617435 | ||||||||
| UniGene | |||||||||
| RefSeq | NP_001040064 | ||||||||
| HUGO | |||||||||
| OMIM | |||||||||
| CCDS | |||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | BC112490 | ||||||||
| GenPept | AAI12491 | ||||||||