InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: C1QA

Summary

InnateDB Protein

IDBP-698210.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

C1QA

Protein Name

Complement C1q subcomponent subunit A

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000009415

InnateDB Gene

IDBG-645509 (C1QA)

Protein Structure

UniProt Annotation

Function

C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.

Predicted by orthology
Total	25 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0002376	immune system process
GO:0006958	complement activation, classical pathway
GO:0045087	innate immune response

Cellular Component

GO:0005576	extracellular region
GO:0005581	collagen trimer
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001073 Complement C1q protein
IPR008160 Collagen triple helix repeat
IPR008983 Tumour necrosis factor-like domain

PFAM

PF00386
PF01391

PRINTS

PR00007

PIRSF

SMART

SM00110

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q5E9E3

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

534961

UniGene

Bt.1577

RefSeq

NP_001014945

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AY911382 BC105345 BT020977

GenPept

AAI05346 AAW82145 AAX08994